Philadelphia Lone Star FC was founded in 2001 as Junior Lone Star FC by West African immigrants, mainly Liberians, in Southwest Philadelphia, Pennsylvania. When the club was founded, most of the team’s players were from Liberia; therefore, the founders decided to name the club Junior Lone Star FC after the Liberia national football team.

In 2001, the club had a single team with 11 players but the club has grown over the years with the addition of three teams with over 70 players. In 2012, the First Team played in its inaugural season in the National Premier Soccer League; while the Reserve Team (U-23) played its inaugural season in the US Club Soccer National Adult League; and the Junior Team (U-19/20) played its inaugural season in the USL Super-20 League.

The club won its first major championship in 2008 when the club’s U-23 team won the Eastern Pennsylvania State U23 Cup. The club’s U23s then represented Eastern Pennsylvania in the 2008 USASA Region I Men’s U-23 Cup where they defeated West Chester United SC and FC Delco in the semi-finals and final, respectively. The club’s U23s subsequently represented USASA Region I at the 2008 USASA National Men’s U-23 Championship where they lost to eventual champions Ela Elite in the semi-finals.

2018 was the club most successful year as the First Team and the Under-23s both qualified for the playoffs for their respective leagues: National Premier Soccer League (First Team) and the United Premier Soccer League (U-23s).

On September 3, 2018, the club rebranded to Philadelphia Lone Star FC.

Philadelphia Lone Star FC is affiliated with the United States Youth Soccer Association(USYSA), the United States Adult Soccer Association (USASA) and the US Soccer Federation (USSF).